| Chemokine, Cc Motif, Receptor 4 | OKDB#: 1695 |
| Symbols: | CCR4 | Species: | zebrafish | ||
| Synonyms: | CKR4|CMKBR4 | Locus: | 3p24 in Homo sapiens |
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For retrieval of Nucleotide and Amino Acid sequences please go to:
OMIM
Entrez Gene
Mammalian Reproductive Genetics Endometrium Database Resource Orthologous Genes UCSC Genome Browser GEO Profiles new! Amazonia (transcriptome data) new! R-L INTERACTIONS MGI |
| General Comment |
Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell
trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors.
Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have
effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines
are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues;
the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines.
NCBI Summary: The protein encoded by this gene belongs to the G-protein-coupled receptor family . It is a receptor for the CC chemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide, structurally related molecules that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. |
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| General function | Receptor | ||||
| Comment | |||||
| Cellular localization | Plasma membrane | ||||
| Comment | |||||
| Ovarian function | Germ cell migration | ||||
| Comment | Doitsidou M, et al 2002 reported the guidance of Primordial Germ Cell Migration by the Chemokine SDF-1. The signals directing primordial germ cell (PGC) migration in vertebrates are largely unknown. The authors demonstrate that sdf-1 mRNA is expressed in locations where PGCs are found and toward which they migrate in wild-type as well as in mutant embryos in which PGC migration is abnormal. Knocking down SDF-1 or its receptor CXCR4 results in severe defects in PGC migration. Specifically, PGCs that do not receive the SDF-1 signal exhibit lack of directional movement toward their target and arrive at ectopic positions within the embryo. Finally, the PGCs can be attracted toward an ectopic source of the chemokine, strongly suggesting that this molecule provides a key directional cue for the PGCs. | ||||
| Expression regulated by | |||||
| Comment | |||||
| Ovarian localization | Primordial Germ Cell | ||||
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| Follicle stages | |||||
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| Phenotypes | |||||
| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
| Links |
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| created: | Jan. 29, 2003, 12:41 p.m. | by: |
hsueh email:
home page: |
| last update: | Feb. 25, 2004, 5:11 p.m. | by: | system email: |
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