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Insulin-like Growth Factor-binding Protein 6 OKDB#: 1653
 Symbols: IGFBP6 Species: human
 Synonyms: IBP6|  Locus: 12 in Homo sapiens


For retrieval of Nucleotide and Amino Acid sequences please go to: OMIM Entrez Gene
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General Comment Six structurally distinct insulin-like growth factor binding proteins have been isolated and their cDNAs cloned: IGFBP1 (146730), IGFBP2 (146731), IGFBP3 (146732), IGFBP4, IGFBP5 (146734), and IGFBP6 (146735). The proteins display strong sequence homologies, suggesting that they are encoded by a closely related family of genes.

General function Extracellular binding protein
Comment
Cellular localization Secreted
Comment
Ovarian function
Comment
Expression regulated by
Comment
Ovarian localization Theca, Stromal cells
Comment Arraztoa JA, et al 2002 analyzed IGFBP mRNA expression patterns in ovaries from mid-cycle rhesus monkeys using in situ hybridization. IGFBP-1 mRNA was concentrated in theca-interstitial cells and was present at low levels in granulosa cells of atretic follicles. IGFBP-2 mRNA was expressed in the ovarian surface epithelium and granulosa cells of all antral follicles, including obviously atretic as well as dominant follicles. IGFBP-3 mRNA was localized in oocytes and in the ovarian vascular endothelium; this mRNA was also concentrated in the superficial cortical stroma in which it was distinctly more abundant in the nondominant ovary. Granulosa cells of mature dominant and ovulatory follicles selectively expressed IGFBP-5 mRNA. IGFBP-5 mRNA was also widely expressed in the ovarian stroma, in which, in contrast to IGFBP-3, it was distinctly more abundant in dominant, compared with nondominant, ovary. IGFBP-6 mRNA was present at low levels in the ovary interstitium and theca externa and was more abundant in the ovary surface epithelium. These novel data reveal distinctive cellular expression patterns for IGFBPs 1, 2, 3, 5, and 6 in the nonhuman primate ovary, suggesting distinct roles for each binding protein in ovarian function.
Follicle stages
Comment
Phenotypes
Mutations 0 mutations
Genomic Region show genomic region
Phenotypes and GWAS show phenotypes and GWAS
Links
OMIM (Online Mendelian Inheritance in Man: an excellent source of general gene description and genetic information.)
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created: Nov. 15, 2002, 10:07 a.m. by: hsueh   email:
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last update: Nov. 15, 2002, 10:07 a.m. by: system    email:



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