| SMOC 1 | OKDB#: 1649 |
| Symbols: | SMOC 1 | Species: | human | ||
| Synonyms: | Locus: |
|
For retrieval of Nucleotide and Amino Acid sequences please go to:
UCSC Genome Browser
GEO Profiles
new!
Amazonia (transcriptome data)
new!
R-L INTERACTIONS MGI |
| General Comment |
Vannahme C, et al 2002
have isolated the novel gene SMOC-1 that encodes a secreted modular protein
containing an EF-hand calcium-binding domain homologous to that in BM-40. It
further consists of two thyroglobulin-like domains, a follistatin-like domain
and a novel domain. Recombinant expression in human cells showed that SMOC-1
is a glycoprotein with a calcium-dependent conformation. Results from Northern
blots, reverse transcriptase-PCR, and immunoblots revealed a widespread
expression in many tissues. Immunofluorescence studies with an antiserum
directed against recombinant human SMOC-1 demonstrated a basement membrane
localization of the protein and additionally its presence in other
extracellular matrices. Immunogold electron microscopy confirmed the
localization of SMOC-1 within basement membranes in kidney and skeletal muscle
as well as its expression in the zona pellucida surrounding the oocyte.
|
|||
| General function | Cell adhesion molecule | |||
| Comment | ||||
| Cellular localization | Secreted | |||
| Comment | ||||
| Ovarian function | Oogenesis | |||
| Comment | ||||
| Expression regulated by | ||||
| Comment | ||||
| Ovarian localization | Oocyte | |||
| Comment | ||||
| Follicle stages | ||||
| Comment | ||||
| Phenotypes | ||||
| Mutations | 0 mutations | |||
| Genomic Region | show genomic region | |||
| Phenotypes and GWAS | show phenotypes and GWAS | |||
| Links |
|
| created: | Nov. 14, 2002, 4:15 a.m. | by: |
hsueh email:
home page: |
| last update: | Nov. 14, 2002, 4:15 a.m. | by: | system email: |
Click here to return to gene search form