| XLR; X-LINKED B CELL SURFACE ANTIGEN, MOUSE, HOMOLOG-LIKE 1; XLRL | OKDB#: 1635 |
| Symbols: | XLR; X-LINKED B CELL SURFACE ANTIGEN, MOUSE, HOMOL | Species: | human | ||
| Synonyms: | Locus: |
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R-L INTERACTIONS MGI |
| General Comment |
The mouse Xlr (X-linked lymphocyte-regulated) gene family was originally identified by
means of subtractive cDNA hybridization and cloning of lymphoid cell-specific mRNAs, followed by selection for X
linkage. The gene was found to encode two 30-kD nuclear proteins expressed in lymphoid cells and in primary
spermatocytes in a developmentally regulated manner.
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| General function | |||||
| Comment | |||||
| Cellular localization | Nuclear | ||||
| Comment | |||||
| Ovarian function | Germ cell development, Oogenesis | ||||
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| Expression regulated by | |||||
| Comment | |||||
| Ovarian localization | Oocyte | ||||
| Comment | Denise Escalier et al 2002 reported Xlr (X Linked, Lymphocyte Regulated), Not Its Male Homologue Xmr (Xlr Related, Meiosis Regulated), Is Expressed in Mouse Oocytes. The Xmr (Xlr related, meiosis regulated) gene product is abundantly expressed in primary spermatocytes and is notably associated with nonrecombining segments of sex chromosomes in the XY body. The authors determined whether Xmr was expressed in meiotic oocytes. This was done by reverse transcription-polymerase chain reaction and cDNA sequencing, Western blot analysis, and immunocytochemistry. Unexpectedly, no Xmr message was detected in mouse fetal oocytes. Instead, Xlr (X linked, lymphocyte regulated), a closely related gene expressed in fetal thymus cells at the time of antigen-receptor gene rearrangement, was expressed in oocytes throughout meiotic prophase I. These findings indicate a sex-specific expression of two closely related members of the Xlr gene family during meiotic prophase I. The XLR protein may provide a useful marker for studies on chromatin condensation or DNA recombination in oocytes. In addition, because of the localization of the Xlr sequence family on the mouse X chromosome, the human equivalent of Xlr is a candidate gene for premature ovarian failure. | ||||
| Follicle stages | |||||
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| Phenotypes | |||||
| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
| Links |
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| created: | Oct. 25, 2002, 1:39 p.m. | by: |
hsueh email:
home page: |
| last update: | Oct. 25, 2002, 1:40 p.m. | by: | system email: |
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