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Hsueh lab

HPMR

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176557

20 beta-Hydroxysteroid dehydrogenase.; 20 beta-HSD OKDB#: 1630
 Symbols: 20 beta-Hydroxysteroid dehydrogenase.; 20 beta-HSD Species: ---
 Synonyms:  Locus:


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General Comment Wang YJ, et al 2002 reported the cloning of 20beta-Hydroxysteroid dehydrogenase. 20beta-HSD is a crucial enzyme that converts 17alpha-hydroxyprogesterone to 17alpha,20beta-dihydroxy-4-pregnen-3-one (DHP), which triggers oocyte maturation in most teleost fish. A full-length cDNA for a carbonyl reductase-like 20beta-HSD (CR/20beta-HSD) has been cloned from the zebrafish ovary. Although the zebrafish CR/20beta-HSD is expressed in all of the tissues tested, it is predominantly expressed in the ovary, testis, kidney, and gill. In the ovary, the enzyme was shown to be expressed in the follicle cells and its expression appeared to be constitutive. No significant difference was noticed in the level of CR/20beta-HSD expression among follicles of different stages. Furthermore, analysis of the ovarian samples taken at different times before spawning showed no significant change of the enzyme expression. In agreement with these results, treatment of the cultured zebrafish ovarian follicle cells with gonadotropin and activin had little effect on the expression of the enzyme. Taken together, these results point to the possibility that the gonadotropin-induced DHP production and final oocyte maturation in the zebrafish may not involve significant change of CR/20beta-HSD expression as evidenced in the salmonids, or that there might be other isoforms of 20beta-HSD whose expression is tightly controlled by endocrine and paracrine factors.

General function Enzyme
Comment
Cellular localization Cytoplasmic
Comment
Ovarian function Steroid metabolism
Comment
Expression regulated by
Comment
Ovarian localization
Comment
Follicle stages
Comment
Phenotypes
Mutations 0 mutations
Genomic Region show genomic region
Phenotypes and GWAS show phenotypes and GWAS
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created: Oct. 22, 2002, 5:42 a.m. by: hsueh   email:
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last update: Oct. 22, 2002, 5:42 a.m. by: system    email:



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