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HPMR

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G protein-coupled receptor 62 OKDB#: 1612
 Symbols: GPR62 Species: human
 Synonyms: GPCR8, KPG_005, MGC26943,  Locus: 3p21.1 in Homo sapiens
HPMR


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General Comment Lee et al. (2001) identified GPR62 within human genomic DNA using GPR61 (OMIM 606916) as probe. Primers to the intronless sequence were synthesized, and GPR62 cDNA was amplified by PCR and cloned. The deduced 368-amino acid protein shares 44% sequence similarity with GPR61 in the transmembrane domain. Northern blot analysis revealed a single 2.3-kb transcript in all brain regions examined, including basal forebrain, frontal cortex, thalamus, caudate, and putamen. No expression was detected in liver. THis orphan receptor was found in a human ovary cDNA library.

NCBI Summary: G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[supplied by OMIM, Feb 2005]
General function Receptor
Comment
Cellular localization Plasma membrane
Comment
Ovarian function
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Expression regulated by
Comment
Ovarian localization
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Follicle stages
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Phenotypes
Mutations 0 mutations
Genomic Region show genomic region
Phenotypes and GWAS show phenotypes and GWAS
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OMIM (Online Mendelian Inheritance in Man: an excellent source of general gene description and genetic information.)
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created: Sept. 13, 2002, 8:53 a.m. by: hsueh   email:
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last update: Oct. 25, 2011, 4:32 p.m. by: hsueh    email:



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