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Hsueh lab

HPMR

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176557

collagen, type XXVI, alpha 1 OKDB#: 1577
 Symbols: COL26A1 Species: human
 Synonyms: EMI6, EMU2, SH2B, EMID2,  Locus: 7q22.1 in Homo sapiens


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General Comment Sato K, et al reported that type XXVI collagen, a new member of the collagen family, is specifically expressed in the testis and ovary. HSP47 is a collagen-specific molecular chaperone that specifically recognizes and binds to the triple helical domain of various types of collagens. The authose report the cloning of the entire coding region of a novel collagen-like protein by yeast two-hybrid screening of a 17.5-day whole mouse embryo cDNA library using HSP47 as a bait. The cDNA of this protein and its deduced amino acid sequence are 2690 bp and 438 amino acids long, respectively. The protein contains two clusters of Gly-X-Y collagenous repeats and three non-collagenous domains. Northern blot analysis showed that its mRNA is specifically expressed in the testis and ovary in adult tissues and that expression in these tissues is highest in the neonate. Biochemical characterization of this protein revealed that its proline residues are hydroxylated, it undergoes N-linked glycosylation, it forms trimers, and it is secreted in vitro. Immunohistochemical studies showed that the myoid cells and the pre-theca cells synthesized it in the testis and ovary, respectively, resulting in the accumulation of this protein in the extracellular spaces of these organs. These observations suggest that this protein is a new member of the collagen protein family.

General function Cell adhesion molecule
Comment
Cellular localization Secreted
Comment
Ovarian function
Comment
Expression regulated by
Comment
Ovarian localization Theca
Comment
Follicle stages
Comment
Phenotypes
Mutations 0 mutations
Genomic Region show genomic region
Phenotypes and GWAS show phenotypes and GWAS
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created: Aug. 14, 2002, 6:51 p.m. by: hsueh   email:
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last update: May 14, 2013, 3:15 p.m. by: hsueh    email:



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