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ARRESTIN, BETA, 2; ARRB2 OKDB#: 1569
 Symbols: ARRESTIN, BETA, 2; ARRB2 Species: human
 Synonyms: BETA-ARRESTIN 2, ARB2|  Locus: 17p13 in Homo sapiens


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General Comment Beta-arrestins were originally discovered in the context of heterotrimeric G protein-coupled receptor desensitization, but they also function in internalization and signaling of these receptors.

NCBI Summary: Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors.
General function
Comment
Cellular localization Plasma membrane
Comment
Ovarian function Follicle development
Comment
Expression regulated by
Comment
Ovarian localization Luteal cells
Comment Hunzicker-Dunn M, et al 2002 reported that ARF6 is a newly appreciated player in G protein-coupled receptor Desensitization. The luteinizing hormone/choriogonadotropin hormone receptor (LH/CG R) signals to regulate ovulation, corpus luteum formation, and fetal survival during pregnancy. Agonist binding to the LH/CG R is poorly reversible, emphasizing the importance of a cellular mechanism to temper signaling by a potentially persistently active receptor. Like other G protein-coupled receptors (GPCRs), signaling by this receptor is modulated by its binding of an arrestin. The authors have identified ADP ribosylation factor 6 (ARF6) as a protein whose activation state is regulated by the LH/CG R and which functions to regulate the availability of plasma membrane-docked arrestin 2 to this receptor.
Follicle stages Corpus luteum
Comment
Phenotypes
Mutations 0 mutations
Genomic Region show genomic region
Phenotypes and GWAS show phenotypes and GWAS
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created: Aug. 6, 2002, 2:09 p.m. by: hsueh   email:
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last update: Aug. 6, 2002, 2:09 p.m. by: system    email:



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