Stanford Home
Ovarian Kaleidoscope Database (OKdb)

Home

History

Transgenic Mouse Models

INFORGRAPHICS

Search
Submit
Update
Chroms
Browse
Admin

Hsueh lab

HPMR

Visits
since 01/2001:
176557

Phosphatidic acid-selective phospholipase A1 OKDB#: 1533
 Symbols: LIPH Species: human
 Synonyms: MEMBRANE-ASSOCIATED PHOSPHATIDIC ACID-SELECTIVE PHOSPHOLIPASE A1,MPAPLA1|PHOSPHOLIPASE A1, PHOSPHATIDIC ACID-SELECTIVE, MEMBRANE-ASSOCIATED|  Locus: 3q27-q28 in Homo sapiens


For retrieval of Nucleotide and Amino Acid sequences please go to: OMIM Entrez Gene
Mammalian Reproductive Genetics   Endometrium Database Resource   Orthologous Genes   UCSC Genome Browser   GEO Profiles new!   Amazonia (transcriptome data) new!

R-L INTERACTIONS   MGI

DNA Microarrays
SHOW DATA ...
link to BioGPS
General Comment Sonoda H, et al 2002 reported a novel phosphatidic acid-selective phospholipase A1 that produces lysophosphatidic acid. Lysophosphatidic acid (LPA) is a lipid mediator with diverse biological properties, although its synthetic pathways have not been solved fully. We report here the cloning and characterization of a novel phosphatidic acid (PA)-selective phospholipase A1 (PLA1) that produces 2-acyl-LPA. The PLA1 was identified in the Genbank data base as a close homologue of phosphatidylserine (PS)-specific PLA1 (PS-PLA1). When expressed in insect Sf9 cells this enzyme was recovered from the Triton X-100 insoluble fraction and did not show any catalytic activity toward exogenously added phospholipid substrates. However, culture medium obtained from Sf9 cells expressing the enzyme was found to activate EDG7/LPA3, a cellular receptor for 2-acyl-LPA. The activation of EDG7 was further enhanced when the cells were treated with phorbol ester or a bacterial phospholipase D, suggesting involvement of phospholipase D in the process. In the latter condition, an increased level of LPA, but not other lysophospholipids, was confirmed by mass spectrometry analyses. Expression of the enzyme is observed in several human tissues such as prostate, testis, ovary, pancreas, and especially platelets. These data show that the enzyme is a membrane-associated PA-selective PLA1 (mPA-PLA1) and suggest that it has a role in LPA production.

General function Enzyme
Comment
Cellular localization Plasma membrane
Comment
Ovarian function
Comment
Expression regulated by
Comment
Ovarian localization
Comment
Follicle stages
Comment
Phenotypes
Mutations 0 mutations
Genomic Region show genomic region
Phenotypes and GWAS show phenotypes and GWAS
Links
OMIM (Online Mendelian Inheritance in Man: an excellent source of general gene description and genetic information.)
OMIM \ Animal Model
KEGG Pathways
Recent Publications
None
Search for Antibody


created: June 25, 2002, 6:57 p.m. by: hsueh   email:
home page:
last update: Nov. 4, 2003, 3:03 p.m. by: system    email:



Use the back button of your browser to return to the Gene List.

Click here to return to gene search form