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Ovarian Kaleidoscope Database (OKdb)

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SH2 DOMAIN PROTEIN 2A; SH2D2A OKDB#: 1481
 Symbols: SH2 DOMAIN PROTEIN 2A; SH2D2A Species: human
 Synonyms: T-CELL SH2 DOMAIN-CONTAINING ADAPTOR PROTEIN, TSAD|  Locus: 1q21 in Homo sapiens


For retrieval of Nucleotide and Amino Acid sequences please go to: OMIM Entrez Gene
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General Comment Many growth factors and hormones modulate the reproductive status in mammals. Among these, insulin and insulin-like growth factor I (IGF-I) regulate the development of gonadal tissues. SH2-B has been shown to interact with insulin and IGF-I receptors, although the role of SH2-B in these signals has not been clarified. SH2-B is downstream of the IGF receptor pathway and was originally identified by using a yeast trihybrid system as a protein associated with an immunoreceptor tyrosine-based activation motif in the high-affinity immunoglobulin E (IgE) receptor Fc-RI. SH2-B contains a proline-rich domain, a Pleckstrin homology (PH) domain, and an SH2 domain.

General function
Comment
Cellular localization Cytoplasmic
Comment
Ovarian function Follicle development, Cumulus expansion
Comment
Expression regulated by
Comment
Ovarian localization Cumulus, Stromal cells
Comment Immunohistochemically stained gonadal tissues (testis and ovary) from wild-type mice indicated that SH2-B was localized in Leydig cells of the testis and stromal cells of the ovary. Ohtsuka S et al 2002
Follicle stages Antral, Preovulatory
Comment
Phenotypes
Mutations 1 mutations

Species: mouse
Mutation name: None
type: null mutation
fertility: infertile - ovarian defect
Comment: Ohtsuka S et al 2002 reported that SH2-B Is Required for Both Male and Female Reproduction. Both male and female SH2-B(-/-) mice showed slight retardation in growth and impaired fertility. Female knockout mice possess small, anovulatory ovaries with reduced numbers of follicles and male SH2-B(-/-) mice have small testes with a reduced number of sperm. SH2-B(-/-) cumulus cells do not respond to either follicle-stimulating hormone or IGF-I. These data suggest that SH2-B plays a critical role in the IGF-I-mediated reproductive pathway in mice.

Genomic Region show genomic region
Phenotypes and GWAS show phenotypes and GWAS
Links
OMIM (Online Mendelian Inheritance in Man: an excellent source of general gene description and genetic information.)
OMIM \ Animal Model
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created: April 17, 2002, 7:57 p.m. by: hsueh   email:
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last update: April 17, 2002, 7:57 p.m. by: system    email:



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