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General Comment |
The EPH and EPH-related receptors comprise the largest subfamily of receptor
protein-tyrosine kinases. They have been implicated in mediating developmental events,
particularly in the nervous system. Receptors in the Eph subfamily typically have a
single kinase domain and an extracellular region containing a Cys-rich domain and 2
fibronectin type III repeats.
NCBI Summary:
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members.
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