|Ephrin Receptor Ephb3||OKDB#: 1479|
|Synonyms:||EPH-LIKE TYROSINE KINASE 2, ETK2| HUMAN EMBRYO KINASE 2, HEK2| TYRO6|||Locus:||3q21-qter in Homo sapiens||HPMR|
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The EPH and EPH-related receptors comprise the largest subfamily of receptor
protein-tyrosine kinases. They have been implicated in mediating developmental events,
particularly in the nervous system. Receptors in the Eph subfamily typically have a
single kinase domain and an extracellular region containing a Cys-rich domain and 2
fibronectin type III repeats.
NCBI Summary: Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members.
|Cellular localization||Plasma membrane|
|Comment||Found in ovarian cDNA library.|
|Expression regulated by|
|Genomic Region||show genomic region|
|Phenotypes and GWAS||show phenotypes and GWAS|
|created:||April 10, 2002, 3:49 p.m.||by:||
|last update:||April 10, 2002, 3:49 p.m.||by:||system email:|
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