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Ovarian Kaleidoscope Database (OKdb)

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Stat 92E OKDB#: 1465
 Symbols: Stat 92E Species: D. melanogaster
 Synonyms:  Locus:


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General Comment STAT proteins have the dual function of signal transduction and activation of transcription (Darnell et al., 1994). These proteins are activated by phosphorylation on tyrosine in response to different ligands after which they form homodimers or heterodimers that translocate to the cell nucleus where they either directly bind to DNA or act together with other DNA-binding proteins in multiprotein transcription complexes to direct transcription.

General function
Comment
Cellular localization Cytoplasmic, Nuclear
Comment
Ovarian function Follicle development
Comment Baksa K, et al 2002 reported the Drosophila STAT protein, Stat92E, regulates follicle cell differentiation during oogenesis. Signal transducer and activator of transcription (STAT) proteins are transcription factors that play a critical role in the response of a variety of eukaryotic cells to cytokine and growth factor signaling. In Drosophila, the STAT homolog encoded by the stat92E gene is required for the normal development of multiple tissues, including embryonic segmentation, imaginal discs, blood cells, male germ cells, and sex determination. We used multiple approaches to study the role of stat92E in oogenesis. Stat92E RNA expression is strongest in the differentiating follicle cells in the germarium, as determined by in situ hybridization. The authors generated an ethylmethane sulfonate-induced, temperature-sensitive allele, stat92E', in which the mutant protein contains a P506S substitution, located in the DNA binding domain. At the restrictive temperature, mutant females are sterile. Mutant ovaries have multiple defects, including fused egg chambers and an absence of interfollicular stalks cells and functional polar follicle cells. An analysis of mosaic clones, using an apparent null stat92E allele, indicates that Stat92E is required in the polar/stalk follicle cell lineage. Thus stat92E is necessary for the early differentiation of follicle cells and for proper germ line cell encapsulation during Drosophila oogenesis.
Expression regulated by
Comment
Ovarian localization
Comment
Follicle stages
Comment
Phenotypes
Mutations 0 mutations
Genomic Region show genomic region
Phenotypes and GWAS show phenotypes and GWAS
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created: March 26, 2002, 8:38 a.m. by: hsueh   email:
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last update: March 26, 2002, 8:38 a.m. by: system    email:



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