| Metallothionein 3 | OKDB#: 1460 |
| Symbols: | MT3 | Species: | human | ||
| Synonyms: | METALLOTHIONEIN III| GROWTH INHIBITORY FACTOR, BRAIN, GIFB| GROWTH INHIBITORY FACTOR, NEUROTROPHIC, GRIF| | Locus: | 16q13 in Homo sapiens |
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| General Comment |
metallothioneins (MTs) as a family of low molecular weight, heavy metal-binding proteins
characterized by a high cysteine content and lack of aromatic amino acids. MTs bind 7 to 12 heavy metal atoms per
molecule of protein. They are ubiquitous in the animal and plant kingdoms and are found in prokaryotes. In mammals, the
cysteine residues are absolutely conserved and serve to coordinate heavy metal atoms such as zinc, cadmium, and copper
via mercaptide linkages.
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| General function | |||||
| Comment | This is one of the metal binding proteins. | ||||
| Cellular localization | Cytoplasmic | ||||
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| Ovarian function | |||||
| Comment | Moffatt P, et al 1998 reported the expression of the gene encoding metallothionein-3 in organs of the reproductive system. Metallothionein-3 (MT-3) is a new MT gene-family member that inhibits survival of rat neurons cultured in presence of brain extracts. Contrary to other MT genes, which are expressed in most tissues and which are highly inducible by metals, MT-3 expression was reported to be mainly in the brain, and it failed to respond to metals in vivo. The authors show that MT-3 mRNA is present in several organs other than the brain, as assayed by Northern analyses. In the rat, MT-3 mRNA was detected in the testis, prostate, epididymis, tongue, ovary, uterus, stomach, heart, and seminal vesicles. The MT-3 mRNA levels in the testis, epididymis, prostate, and tongue were 22% of those in brain, while in ovary, uterus, and stomach, they were 4% of the brain level, and they were lower still in the other organs. | ||||
| Expression regulated by | |||||
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| Ovarian localization | |||||
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| Follicle stages | |||||
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| Phenotypes | |||||
| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
| Links |
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| created: | March 18, 2002, 5 p.m. | by: |
hsueh email:
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| last update: | March 18, 2002, 5 p.m. | by: | system email: |
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