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since 01/2001:

oncostatin M receptor OKDB#: 1457
 Symbols: OSMR Species: human
 Synonyms: OSMRB, PLCA1, IL-31RB, IL-31R-beta  Locus: 5p13.1 in Homo sapiens

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General Comment NCBI Summary: This gene encodes a member of the type I cytokine receptor family. The encoded protein heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events. Mutations in this gene have been associated with familial primary localized cutaneous amyloidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]
General function Receptor
Cellular localization Plasma membrane
Ovarian function
Expression regulated by LH
Ovarian localization Oocyte, Granulosa, Luteal cells
Comment Immunocytochemical detection and reverse transcription polymerase chain reaction expression of oncostatin M (OSM) and its receptor (OSM-Rbeta) in human fetal and adult ovaries Abir R, et al . OBJECTIVE: To investigate the immunocytochemical expression and presence of mRNA transcripts of oncostatin M (OSM) and its exclusive receptor (OSM-Rbeta) in ovaries from human adults and fetuses. DESIGN: Immunocytochemical and reverse transcription polymerase chain reaction (RT-PCR) study. SETTING: Major tertiary care and referral academic centers. PATIENT(S): Ten women and girls undergoing laparoscopic ovarian biopsy and 30 women undergoing second-trimester and third-trimester pregnancy terminations. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Microscopic morphometric analysis, immunocytochemistry for OSM and OSM-Rbeta, and RT-PCR analyses. RESULT(S): There was strong to moderate immunocytochemical staining for OSM in both oocytes and granulosa cells of follicles from primordial stages onwards in ovaries from both fetuses and adults/adolescents. OSM-Rbeta was detected mainly in the oocytes. Transcripts of OSM and OSM-Rbeta RNA were detected by RT-PCR analyses. CONCLUSION(S): The expression of OSM and its receptor in ovarian tissue from fetuses and women suggests a possible role of OSM in growth initiation of human primordial follicles.
Follicle stages Corpus luteum
Comment Oncostatin M and its receptors mRNA regulation in bovine granulosa and luteal cells. Martins KR et al. (2018) Oncostatin M (OSM) and its receptor (OSMR) are members of the interleukin-6 family cytokines. Although OSM and OSMR expression was detected in human ovaries, their function and regulation during follicle development, ovulation and luteolysis have not been studied in any species. The aim of the present study was to investigate the levels of OSM and OSMR mRNA in bovine ovaries and the effect of OSM treatment on cultured granulosa cells. OSM mRNA was not detected in granulosa cells obtained from follicles around the time of follicular deviation and from pre-ovulatory follicles, whereas OSMR transcript levels were greater in granulosa cells of atretic subordinate follicles (P&#x202F;<&#x202F;0.001). Abundance of OSMR mRNA increased in granulosa cells of preovulatory follicles, collected at 12 and 24&#x202F;h after the ovulatory stimulus with gonadotropins (P&#x202F;<&#x202F;0.001). In the luteal tissue, OSM mRNA abundance levels were higher at 24-48&#x202F;h after PGF-induced luteolysis (P&#x202F;<&#x202F;0.01) compared to 0&#x202F;h, whereas OSMR mRNA was transiently increased at 2&#x202F;h after PGF treatment (P&#x202F;<&#x202F;0.05). In cultured granulosa cells, 10&#x202F;ng/mL OSM in the presence of FSH increased BAX/BCL2 mRNA ratio (P&#x202F;<&#x202F;0.05) compared to the control. Moreover, 100&#x202F;ng/mL OSM in the presence of FSH increased OSMR (P&#x202F;<&#x202F;0.05) and decreased XIAP mRNA (P&#x202F;<&#x202F;0.05) levels, compared to the control group. These findings provide the first evidence that OSMR is regulated during follicle atresia, ovulation and luteolysis, and that OSM from other cells may mediate granulosa and luteal cell function, regulating the expression of genes involved in cell's viability.//////////////////
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created: March 15, 2002, 10:11 a.m. by: hsueh   email:
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last update: Dec. 11, 2018, 1:28 p.m. by: hsueh    email:

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