| Calcium-modulating Cyclophilin Ligand | OKDB#: 1414 |
| Symbols: | CAMLG | Species: | human | ||
| Synonyms: | CAML | Locus: | 5q23 in Homo sapiens |
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| General Comment |
Calcium-modulating cyclophilin ligand was discovered by Bram and Crabtree (1994) in a 2-hybrid screen for signaling
molecules that interact with cyclophilin B
NCBI Summary: The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin. |
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| General function | Ligand | ||||
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| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
| Links |
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| created: | Jan. 17, 2002, 1:26 p.m. | by: |
hsueh email:
home page: |
| last update: | Feb. 27, 2004, 12:25 p.m. | by: | system email: |
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