The lysolipid mediator lysophosphatidic acid (LPA) is generated by phospholipase cleavage of membrane phospholipids from
stimulated cells and platelets. LPA is present at micromolar concentrations in serum, and it elicits diverse biologic functions,
including proliferation, platelet aggregation, smooth muscle contraction, inhibition of neuroblastoma cell differentiation,
chemotaxis, and tumor cell invasion. LPA and the structurally related lysolipid mediator sphingosine 1-phosphate (S1P) signal
cells through a set of G protein-coupled receptors known as EDG receptors.
NCBI Summary:
This gene encodes a member of the G protein-coupled receptor family, as well as the EDG family of proteins. This protein functions as a cellular receptor for lysophosphatidic acid and mediates lysophosphatidic acid-evoked calcium mobilization. This receptor couples predominantly to G(q/11) alpha proteins.
General function
Receptor
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Cellular localization
Plasma membrane
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Ovarian function
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Expression regulated by
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Ovarian localization
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Northern blot analysis detected a 4.3-kb EDG7 transcript in heart, pancreas,
prostate, and testis, with lower expression in lung, ovary, and some cancer cell lines.Bandoh et al 1999