|
General Comment |
Cox DN, et al 2001 reported that
Bazooka and atypical protein kinase C are required to regulate
oocyte differentiation in the Drosophila ovary.
The par genes, identified by their role in the establishment of
anterior-posterior polarity in the Caenorhabditis elegans zygote, subsequently
have been shown to regulate cellular polarity in diverse cell types by means
of an evolutionarily conserved protein complex including PAR-3, PAR-6, and
atypical protein kinase C (aPKC). The Drosophila homologs of par-1, par-3
(bazooka, baz), par-6 (DmPar-6), and pkc-3 (Drosophila aPKC, DaPKC) each are
known to play conserved roles in the generation of cell polarity in the germ
line as well as in epithelial and neural precursor cells within the embryo. in
light of this functional conservation, the authors examined the potential role of baz
and DaPKC in the regulation of oocyte polarity and reveal germ-line
autonomous roles for baz and DaPKC in the establishment of initial
anterior-posterior polarity within germ-line cysts and maintenance of oocyte
cell fate. Germ-line clonal analyses indicate both proteins are essential for
two key aspects of oocyte determination: the posterior translocation of oocyte
specification factors and the posterior establishment of the microtubule
organizing center within the presumptive oocyte. BAZ and DaPKC
colocalize to belt-like structures between germarial cyst cells.
Huynh J, et al reported that Bazooka and PAR-6 are required with PAR-1 for the
maintenance of oocyte fate in Drosophila.
|