The matrix metalloproteinases (MMPs) are a group of structurally related zinc-dependent endopeptidases that mediate
the degradation of extracellular matrix components. The human MMP family can be classified into at least 4
subfamilies: collagenases, stromelysins, gelatinases, and membrane-type MMPs.
General function
Enzyme, Peptidase/Protease
Comment
Cellular localization
Secreted
Comment
Ovarian function
Ovulation, Follicle rupture
Comment
Atsushi Kimura et al 2001 reported localization of Bradykinin B2 Receptor in the Follicles of Porcine Ovary and Increased Expression
of Matrix Metalloproteinase-3 and -20 in Cultured Granulosa Cells by
Bradykinin Treatment.
The effect of bradykinin on the expression of some
matrix metalloproteinase (MMP) genes was examined using isolated granulosa cells. Bradykinin treatment induced
MMP-3 and MMP-20 gene expression to an extreme degree. The expression of MT1-MMP was also affected by
bradykinin treatment. These results suggest that MMPs play a role in follicle rupture during ovulation. The present study
provides new information regarding the mechanisms of bradykinin-induced ovulation in porcine ovaries.