| G protein-coupled receptor 68 | OKDB#: 1273 |
| Symbols: | GPR68 | Species: | human | ||
| Synonyms: | OGR1, AI2A6, GPR12A | Locus: | 14q32.11 in Homo sapiens | HPMR |
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For retrieval of Nucleotide and Amino Acid sequences please go to:
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Entrez Gene
Mammalian Reproductive Genetics Endometrium Database Resource Orthologous Genes UCSC Genome Browser GEO Profiles new! Amazonia (transcriptome data) new! R-L INTERACTIONS MGI |
| General Comment |
GPR68 Senses Flow and Is Essential for Vascular Physiology.
A Mechanosensitive GPCR that Detects the Bloody Force. CELL 2018
Xu and Casey (1996) described a gene encoding a member of the G protein-coupled receptors that they termed ovarian
cancer G protein-coupled receptor-1 (OGR1). It was isolated by degenerate PCR from an ovarian cell line cDNA library.
NCBI Summary: The protein encoded by this gene is a G protein-coupled receptor for sphingosylphosphorylcholine. The encoded protein is a proton-sensing receptor, inactive at pH 7.8 but active at pH 6.8. Mutations in this gene are a cause of amelogenesis imperfecta. [provided by RefSeq, Feb 2017] |
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| General function | Receptor | ||||
| Comment | |||||
| Cellular localization | Plasma membrane | ||||
| Comment | |||||
| Ovarian function | Tumorigenesis | ||||
| Comment | |||||
| Expression regulated by | |||||
| Comment | |||||
| Ovarian localization | Oocyte | ||||
| Comment | goes up in a follicle stage-dependent manner in oocytes | ||||
| Follicle stages | Antral, Preovulatory | ||||
| Comment | |||||
| Phenotypes | |||||
| Mutations | 0 mutations | ||||
| Genomic Region | show genomic region | ||||
| Phenotypes and GWAS | show phenotypes and GWAS | ||||
| Links |
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| created: | Aug. 28, 2001, 3:52 p.m. | by: |
hsueh email:
home page: |
| last update: | April 20, 2018, 12:14 p.m. | by: | hsueh email: |
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