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HPMR

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Spondin 1 OKDB#: 1216
 Symbols: SPON1 Species: human
 Synonyms: F-SPONDIN, RAT, HOMOLOG OF|  Locus: 11 in Homo sapiens


For retrieval of Nucleotide and Amino Acid sequences please go to: OMIM Entrez Gene
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General Comment A protein possessing vascular smooth muscle cell (SMC) growth-promoting activity (VSGP) was purified from bovine ovarian follicular fluid. The purified protein showed a broad band on SDS-PAGE with an apparent molecular mass of 90-100 kDa, The purified protein was characterized by amino acid sequence analysis of its N-terminal and internal peptides. Based on the information of the peptide sequences, bovine ovarian cDNA library was screened and cDNA clones encoding the protein were isolated. Human homolog of the protein was also cloned from human ovarian cDNA library. Nucleotide sequence analysis revealed that bovine VSGP transcript has a 2421-bp open reading frame, which encodes a protein of 807 amino acid residues. A homology search indicated that bovine and human VSGP are counterparts of rat F-spondin, which has been previously identified as a promoter molecule of neurite extension in rat fetal floor plate.

NCBI Summary: Very strongly similar to rat F-spondin (Rn.7546); may have a role in the growth and guidance of axons
General function Ligand, Growth factor
Comment
Cellular localization Secreted
Comment
Ovarian function
Comment Miyamoto K, et al 2001 reported the isolation and characterization of vascular smooth muscle cell growth promoting factor from bovine ovarian follicular fluid and its cDNA cloning from bovine and human ovary. RNA blot analysis showed wide distribution of VSGP/F-spondin transcripts in fetal and adult human tissues. Especially the expression was highest in the adult human ovary. The purified bovine VSGP/F-spondin showed vascular SMC growth promoting activity with an ED,, value of 10(-8) M. Together with these findings, we demonstrated here that VSGP/F-spondin is a major factor for vascular SMC proliferation in the ovary.
Expression regulated by
Comment
Ovarian localization Ovarian tumor
Comment VSGP/F-Spondin: A New Ovarian Cancer Marker. Tumour Biol. 2005 Aug 9;26(5):245-257..
Follicle stages
Comment
Phenotypes
Mutations 0 mutations
Genomic Region show genomic region
Phenotypes and GWAS show phenotypes and GWAS
Links
OMIM (Online Mendelian Inheritance in Man: an excellent source of general gene description and genetic information.)
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created: July 3, 2001, 8:58 a.m. by: hsueh   email:
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last update: Jan. 29, 2010, 1:47 p.m. by: hsueh    email:



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