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Hsueh lab

HPMR

Polymerase, Dna, Beta

OKDB#: 1208

	Symbols:	POLB		Species:	human
	Synonyms:			Locus:	8p11.2 in Homo sapiens

For retrieval of Nucleotide and Amino Acid sequences please go to: OMIM Entrez Gene
Mammalian Reproductive Genetics Endometrium Database Resource Orthologous Genes UCSC Genome Browser GEO Profiles ^new! Amazonia (transcriptome data) ^new!
R-L INTERACTIONS MGI

General Comment

On the basis of inhibitor studies of mammalian cells after DNA damage with various agents, it can be shown that both DNA polymerase alpha (OMIM:312040) and DNA polymerase beta play synthetic roles in DNA repair pathways.

NCBI Summary: In eukaryotic cells, DNA polymerase beta (POLB) performs base excision repair (BER) required for DNA maintenance, replication, recombination, and drug resistance. Also see POLA (MIM 312040).[supplied by OMIM]

General function

Cell death/survival, DNA Replication, Enzyme, Transferase, Lyase

Comment

Cellular localization

Nuclear

Comment

Ovarian function

Oogenesis, Oocyte maturation

Comment

Murdock WJ, et al MOLECULAR REPRODUCTION AND DEVELOPMENT 2001] reported the estrogenic upregulation of DNA polymerase beta in oocytes of preovulatory ovine follicles. The basic premise of this investigation was that local hormonal control of stockpiling of the base excision repair polymerase (poly) beta within oocytes of preovulatory follicles occurs as a function of cytoplasmic maturation. There was an increase in immunoreactive poly beta in sectioned oocytes of preovulatory ovine follicles during a 12-36-hour interval following the onset of prostaglandin (PG) F(2)alpha -induced (Day 14 of the estrous cycle) luteal regression; this response was not observed in subordinate (nonovulatory) follicles. Estradiol-17 beta stimulated poly beta expression (transcriptional control) in oocytes of explanted (12 hr after PGF2a) follicles (24-hour incubation). We suggest that a critical period of estrogen amplification in the preovulatory follicle underscores the capacity of its oocyte to efficiently repair DNA and therefore reconcile spontaneous infidelities in genomic integrity that inevitably occur during preimplantation embryogenesis. Gene whose expression is detected by cDNA array hybridization: GDP/GTP exchangers, GTPase stimulators and inhibitors, apoptosis. [Rozenn Dalbi?Tran and Pascal Mermilloda

Expression regulated by

Comment

Ovarian localization

Oocyte

Comment

Follicle stages

Comment

Phenotypes

Mutations

0 mutations

Genomic Region

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Phenotypes and GWAS

show phenotypes and GWAS

Links

OMIM (Online Mendelian Inheritance in Man: an excellent source of general gene description and genetic information.)
OMIM \ Animal Model
KEGG Pathways

Recent Publications

None

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created:

June 27, 2001, 11:37 a.m.

by:

hsueh email:
home page:

last update:

July 26, 2006, 11:45 a.m.

by:

Alex email:

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