Stanford Home
Ovarian Kaleidoscope Database (OKdb)

Home

History

Transgenic Mouse Models

INFORGRAPHICS

Search
Submit
Update
Chroms
Browse
Admin

Hsueh lab

HPMR

Visits
since 01/2001:
176557

Adenylate Cyclase 1 OKDB#: 1203
 Symbols: ADCY1 Species: human
 Synonyms: ADENYLYL CYCLASE, FETAL BRAIN, TYPE I|  Locus: 7p13-p12 in Homo sapiens


For retrieval of Nucleotide and Amino Acid sequences please go to: OMIM Entrez Gene
Mammalian Reproductive Genetics   Endometrium Database Resource   Orthologous Genes   UCSC Genome Browser   GEO Profiles new!   Amazonia (transcriptome data) new!

R-L INTERACTIONS   MGI

DNA Microarrays
SHOW DATA ...
link to BioGPS
General Comment Adenylyl cyclase is the prototypical second messenger generator. There are at least nine eight cloned membrane-bound adenylyl cyclases together with the testis soluble adenyl cyclase. The membrane bound enzymes are regulated by diverse G proteins and are regulated by one or other arm of the phospholipase C pathway. In addition to ligand-mediated signaling via G proteins, functional and ultrastructural investigations have shown that adenylyl cyclases are also intimately associated with sites of calcium ion entry into the cell.

NCBI Summary: This gene encodes a form of adenylate cyclase expressed in brain. A similar protein in mouse is involved in pattern formation of the brain.
General function Intracellular signaling cascade, Enzyme, Transferase
Comment
Cellular localization Plasma membrane
Comment
Ovarian function Follicle development, Follicle atresia, Ovulation, Steroid metabolism, Luteinization, Oogenesis, Oocyte maturation
Comment Genes whose expression is detected by cDNA array hybridization: GDP/GTP exchangers, GTPase stimulators and inhibitors, apoptosis Rozenn Dalbis-Tran and Pascal Mermilloda
Expression regulated by
Comment
Ovarian localization Granulosa
Comment Asboth G, et al 2001 reported the characterization of adenylyl cyclases in cultured human granulosa cells. Many functions of granulosa-lutein cells are controlled by activation of C protein-coupled receptors and the formation of cyclic AMP (cAMP) by adenylyl cyclase. There are at least nine mammalian adenylyl cyclase isoenzymes, which show different sensitivities towards other signalling systems. Granulosa cells were obtained from women undergoing IVF. The cells were maintained in primary culture and they consistently expressed mRNA coding for adenylyl cyclase I, III, VI, VII and IX. These results indicate that subtypes adenylyl cyclase I, III and VIII, which are activated by calcium, and adenylyl cyclase V and VI, which are inhibited by calcium, are not dominant isoforms in granulosa-lutein cells. The protein kinase A inhibitor H89 had no effects on formation of cAMP; this finding rules out the involvement of adenylyl cyclase V and VI subtypes, which are subjected to negative feedback by protein kinase A. These results indicate that adenylyl cyclase VII is the dominant functional isoenzyme in human granulosa-lutein cells.
Follicle stages Preovulatory
Comment
Phenotypes
Mutations 0 mutations
Genomic Region show genomic region
Phenotypes and GWAS show phenotypes and GWAS
Links
OMIM (Online Mendelian Inheritance in Man: an excellent source of general gene description and genetic information.)
OMIM \ Animal Model
KEGG Pathways
Recent Publications
http://stke.sciencemag.org/cgi/cm/CMP_6634
Search for Antibody


created: June 27, 2001, 10:46 a.m. by: hsueh   email:
home page:
last update: July 26, 2006, 11:04 a.m. by: Alex    email:



Use the back button of your browser to return to the Gene List.

Click here to return to gene search form