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Interferon Regulatory Factor 1 OKDB#: 1175
 Symbols: IRF1 Species: human
 Synonyms:  Locus: 5q31.1 in Homo sapiens


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General Comment Interferon regulatory factor-1 (IRF1) binds to the upstream cis elements of both the interferon-alpha and the interferon-beta genes. It was found that IRF1 functions as a transcriptional activator for the type I IFN genes.

NCBI Summary: IRF1 encodes interferon regulatory factor 1, a member of the interferon regulatory transcription factor (IRF) family. IRF1 serves as an activator of interferons alpha and beta transcription, and in mouse it has been shown to be required for double-stranded RNA induction of these genes. IRF1 also functions as a transcription activator of genes induced by interferons alpha, beta, and gamma. Further, IRF1 has been shown to play roles in regulating apoptosis and tumor-suppressoion.
General function Nucleic acid binding, DNA binding, Transcription factor
Comment
Cellular localization Nuclear
Comment
Ovarian function Luteinization, Oocyte maturation
Comment Expression of interferon regulatory factor-1 in the mouse cumulus-oocyte complex is negatively related with oocyte maturation. Kim YS et al. We found previously that interferon regulatory factor (Irf)-1 is a germinal vesicle (GV)-selective gene that highly expressed in GV as compared to metaphase II oocytes. To our knowledge, the function of Irf-1 in oocytes has yet to be examined. The present study was conducted to determine the relationship between retinoic acid (RA) and RA-mediated expression of Irf-1 and the mouse oocyte maturation.
Expression regulated by Growth Factors/ cytokines
Comment
Ovarian localization Oocyte, Cumulus, Luteal cells
Comment Suter J, et al 2001 reported the mediators of interferon gamma-initiated signaling in bovine luteal cells. Interferon gamma (IFN gamma) has been implicated as a mediator of luteal steroidogenesis and cell fate. IFN gamma -initiated signaling events, although implied by studies in cell lines, have yet to be described in primary luteal cells. Dispersed bovine luteal cell cultures were challenged with increasing levels of bovine recombinant IFN gamma (0-1000 U) or IFN gamma (200 U) in the presence or absence of tumor necrosis factor cu (TNF alpha, 10 ng/ml) over time (short term, 0-60 min; long term, 0, 24, 48 h). Fractionated or total cell lysates were evaluated by the Western blotting technique to determine the changes in the levels of signal transducers and activators of transcription (STAT), interferon regulatory factor 1 (IRF-1), and I kappa B alpha (I kappaB-alpha). Utilizing antibodies that recognize the nonphosphorylated forms of STAT-1 and STAT-3, it was determined that levels of STAT-1 and STAT-3 in total cell lysates were constitutively expressed and did not change in response to treatment with IFN gamma or TNFa. In contrast, nuclear levels of STAT-1 and phosphorylated STAT-3 were elevated in a time-dependent manner in response to IFN gamma treatment. Furthermore, IFN gamma and TNF alpha treatment elevated levels of IRF-1 within 2 h. TNF alpha -induced increases in the levels of IRF-1 were transient, whereas the levels of IRF-1 in response to IFN gamma treatment remained elevated at 48 h.
Follicle stages Corpus luteum
Comment
Phenotypes
Mutations 0 mutations
Genomic Region show genomic region
Phenotypes and GWAS show phenotypes and GWAS
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created: May 27, 2001, 3:48 p.m. by: hsueh   email:
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last update: March 7, 2012, 10:48 a.m. by: hsueh    email:



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