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Dead/h Box 16 OKDB#: 1152
 Symbols: DDX16 Species: human
 Synonyms: DEAH-BOX PROTEIN 2, DBP2| PRP8, S. POMBE, HOMOLOG OF|  Locus: 6p21.3 in Homo sapiens


For retrieval of Nucleotide and Amino Acid sequences please go to: OMIM Entrez Gene
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General Comment DEAD/H box proteins are putative RNA helicases that have a characteristic Asp-Glu-Ala-Asp (DEAD) box as one of several highly conserved sequence motifs. The S. pombe prp8/cdc28 DEAH box protein is involved in cell cycle progression and has sequence similarity to several S. cerevisiae DEAH box proteins that act as splicing factors.

General function Cell proliferation
Comment
Cellular localization Nuclear
Comment
Ovarian function
Comment
Expression regulated by
Comment
Ovarian localization Granulosa
Comment Takahashi A, et al reported that a splicing factor, Prp8: Preferential localization in the testis and ovary in adult mice. Prp8 is a splicing factor of 220 kDa originally identified in yeast and is a component of the U5 small nuclear ribonucleoprotein particle. Mouse PrpS cDNA was cloned and shown to share 62.6 and 68.2% sequence identity with the yeast homologue at the amino acid and nucleotide level, respectively, while it differs by only 3 amino acid residues from the human homologue, During mouse embryogenesis, Prp8 is expressed intensely at day 9.5 of gestation, and its expression decreases progressively during embryogenesis. In adult mice, Prp8 is expressed strongly in the testis and moderately in the ovary. In situ hybridization analysis revealed that Prp8 is preferentially expressed in the outer cell layer in the testis, probably in the spermatogonia and primary spermatocytes, and in granulosa cells in the ovary. In Caenorhabditis elegans, microinjection of a double stranded RNA corresponding to a portion of the Prp8 sequence results in the arrest of embryogenesis at the late-gastrulation stage. These results suggest that Prp8 plays an important role in reproduction and development. Prp8 was shown to bind to midkine (MK), a heparin-binding growth factor. Since Prp8 expression partially overlaps with the sites of action of MK, it is possible that binding to PrpS is involved in part of MK signaling.
Follicle stages
Comment
Phenotypes
Mutations 0 mutations
Genomic Region show genomic region
Phenotypes and GWAS show phenotypes and GWAS
Links
OMIM (Online Mendelian Inheritance in Man: an excellent source of general gene description and genetic information.)
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created: April 25, 2001, 1:17 p.m. by: hsueh   email:
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last update: Aug. 13, 2001, 2:49 p.m. by: hsueh    email:



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